The Mission is hot, hot, hot! It’s been speculated to be the place of change since the 1980’s and in the last expansion starting around 2011, it really did. I consider the Mission New York-ish. Lots of activity, options, diversity and some really fantastic restaurants and shops in the middle of areas you wouldn’t expect.
Bernal Heights has changed tremendously over the years I’ve been in SF. It really is it’s own village, with Cortland Ave as its hub. The houses have a bit of Bernal Heights funk, with a bohemian flare.
Potrero is a city within a city. The view vantage points are astounding; looking at downtown SF, but maintaining its own identity. Convenient to I-280, the area is popular to residents commuting down the peninsula for their tech jobs. 18th St. is the main commercial hub with neighborhood haunts including a wine bar, cute shops and some very good restaurants, including a Potrero Hill staple-Goat Hill Pizza.
SOMA is still quite industrial; the fabric includes loft developments scattered throughout. Commercial areas are scattered throughout; make sure and visit South Park-a very cool urban park is at the center and is very active at lunch time.